Prmt1 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comPrmt1 CLIA Kit for Rat(Rattus norvegicus)

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Prmt1 (Gene name),

Protein arginine N-methyltransferase 1 (Protein name ), ANM1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Prmt1(Hrmt1l2);

Protein name:

Protein arginine N-methyltransferase 1;

Alternative:

2.1.1.125;Histone-arginine N-methyltransferase PRMT1);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1 (By similarity). Interacts with NFATC2IP.

Function:

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.

Subcellular Location:

Nucleus Cytoplasm cytosol

Protein Attributes:

Sequence length:

353

Sequence:

50:

100:

150:

200:

250:

300:

350:

353:

RMR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q63009

Pfam:

PF13847

UniGene:

Rn.5870

STRING:

10116.ENSRNOP00000027761

KEGG:

rno:60421

SMR:

Q63009

Uniprot:

Q63009

FOR

ELISA Kit for Rat Protein arginine N-methyltransferase 1

Cat.:

E15261h

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96T

ELISA Kit for Rat Protein arginine N-methyltransferase 1

Cat.:

E15261r

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96T

ELISA Kit for Rat Protein arginine N-methyltransferase 1

Cat.:

E15261m

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Packing:

96T

CLIA Kit for Rat Protein arginine N-methyltransferase 1

Cat.:

U15261r

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Protein arginine N-methyltransferase 1

Cat.:

U15261m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Protein arginine N-methyltransferase 1

Cat.:

U15261h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Protein arginine N-methyltransferase 1

Cat.:

P15261Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Protein arginine N-methyltransferase 1

Cat.:

P15261Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Protein arginine N-methyltransferase 1

Cat.:

P15261Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Protein arginine N-methyltransferase 1

Protein for Rat Protein arginine N-methyltransferase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase."
Lin W.-J. , Gary J.D. , Yang M.C. , Clarke S. , Herschman H.R.
J. Biol. Chem.271:15034-15044(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH BTG1; BTG2 AND IFNAR1
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
3.

"Multimerization of expressed protein-arginine methyltransferases during the growth and differentiation of rat liver."
Lim Y. , Kwon Y.H. , Won N.H. , Min B.H. , Park I.S. , Paik W.K. , Kim S.
Biochim. Biophys. Acta1723:240-247(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
4.

"Involvement of PRMT1 in hnRNPQ activation and internalization of insulin receptor."
Iwasaki H.
Biochem. Biophys. Res. Commun.372:314-319(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides."
Zhang X. , Cheng X.
Structure11:509-520(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE AND PEPTIDE SUBSTRATE;SUBUNIT;FUNCTION;ACTIVE SITE;MUTAGENESIS OF GLU-144 AND GLU-153

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